Model Organisms: Grandeur in the Diversity of Aging Organisms
نویسندگان
چکیده
منابع مشابه
Reproductive aging: insights from model organisms.
Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms and are potentially manipulable, suggesting the possibility of treatment for age-related disorders. Reproductive decline is one aspect o...
متن کاملModel organisms
The explosion of genomic information and the need to search for gene homologies make it more important than ever that genetic and biochemical data from model organisms should be organized in an accessible way — which is where online databases come into their own. In previous issues, The spider dealt with online resources for yeast and Caenorhabditis elegans (see Curr Biol 1998, 8:R670), Escheri...
متن کاملModel organisms
For more than a century, research scientists have been accumulating genetic and biochemical data on model organisms. Now, the explosion of genomic information and the need to search for gene homologies makes it more important than ever that these data should be organized in an accessible way — which is where online databases come into their own. The Spider kicks off with yeast and Caenorhabditi...
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Invertebrate model systems, such as nematodes and fruit flies, have provided valuable information about the genetics and cellular biology involved in aging. However, limitations of these simple, genetically tractable organisms suggest the need for other model systems, some of them invertebrate, to facilitate further advances in the understanding of mechanisms of aging and longevity in mammals, ...
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Many increasingly prevalent diseases share a common risk factor: age. However, little is known about pharmaceutical interventions against aging, despite many genes and pathways shown to be important in the aging process and numerous studies demonstrating that genetic interventions can lead to a healthier aging phenotype. An important challenge is to assess the potential to repurpose existing dr...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2020
ISSN: 2399-5300
DOI: 10.1093/geroni/igaa057.2667